Bayesian optimization with evolutionary and structure-based regularization for directed protein evolution
Background: Directed evolution (DE) is a technique for protein engineering that involves iterative rounds of mutagenesis and screening to search for sequences that optimize a given property, such as binding affinity to a specified target. Unfortunately, the underlying optimization problem is under-d...
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |