VCP suppresses proteopathic seeding in neurons

VCP suppresses proteopathic seeding in neurons

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Background: Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly understood. One proteinopathy called multisystem proteinopathy (MSP) is associated w...

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Bibliographic Details
Main Authors: Ayala, Y. (Author), Bieschke, J. (Author), Buscher, W.J (Author), Clemen, C.S (Author), Davis, A.A (Author), Dhavale, D. (Author), Diamond, M.I (Author), French, R. (Author), Kaleelurrrahuman, M.S (Author), Kotzbauer, P. (Author), Maggiore, G. (Author), Patterson, J.N (Author), Pittman, S. (Author), Sun, Y. (Author), Vaquer-Alicea, J. (Author), Weihl, C. (Author), Zhu, J. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Alpha-synuclein
animal
Animals
CRISPR screen
DNA binding protein
DNA-Binding Proteins
Frontotemporal dementia
genetics
human
Humans
metabolism
Mice
mouse
mutation
Mutation
nerve cell
Neurons
Seeding
TDP-43
valosin containing protein
Valosin Containing Protein
VCP protein, human
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