Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia

Background: Relapsed acute myeloid leukemia (AML) is associated with the acquisition of additional somatic mutations which are thought to drive phenotypic adaptability, clonal selection and evolution of leukemic clones during treatment. We performed high throughput exome sequencing of matched presen...

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Bibliographic Details
Main Authors:	Abdullah, J. (Author), Abu Seman, Z. (Author), Ahid, F. (Author), Esa, E. (Author), Kamaluddin, N.R (Author), Mat Yusoff, Y. (Author), Zakaria, Z. (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2021
Series:	Molecular Cytogenetics
Subjects:	acute myeloid leukemia Acute myeloid leukemia adolescent adult allele Article cancer combination chemotherapy clinical article clonal evolution Clonal evolution consolidation chemotherapy cytarabine cytogenetically normal acute myeloid leukemia daunorubicin drug megadose FLT3 ITD gene gene high throughput sequencing human idarubicin IDH2 gene indel mutation induction chemotherapy leukemia relapse middle aged Mutation mutational analysis NPM1 gene oncogene N ras Relapse single nucleotide polymorphism somatic mutation variant allele fraction whole exome sequencing Whole exome sequencing
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Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemia

Internet

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