A comparative study on the unified model based multifactor dimensionality reduction methods for identifying gene-gene interactions associated with the survival phenotype

A comparative study on the unified model based multifactor dimensionality reduction methods for identifying gene-gene interactions associated with the survival phenotype

Background: For gene-gene interaction analysis, the multifactor dimensionality reduction (MDR) method has been widely employed to reduce multi-levels of gene-gene interactions into high- or low-risk groups using a binary attribute. For the survival phenotype, the Cox-MDR method has been proposed usi...

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Bibliographic Details
Main Authors: Lee, J.W (Author), Lee, S. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
acute myeloid leukemia
Article
cancer survival
controlled study
Cox model
cross validation
DCTD gene
gene
gene frequency
gene interaction
Gene-gene interaction
genetic association
genetic linkage
genetic risk
genotype
Hardy Weinberg equilibrium
heritability
high risk patient
human
Kaplan-Meier estimate
Korean (people)
low risk patient
median survival time
multifactor dimensionality reduction
Multifactor dimensionality reduction method
NQO1 gene
population genetic phenomena and functions
priority journal
proportional hazards model
single nucleotide polymorphism
Survival time
systematic error
Unified model-based method
validity
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