Coupling sparse Cox models with clustering of longitudinal transcriptomics data for trauma prognosis

Background: Longitudinal gene expression analysis and survival modeling have been proved to add valuable biological and clinical knowledge. This study proposes a novel framework to discover gene signatures and patterns in a high-dimensional time series transcriptomics data and to assess their associ...

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Bibliographic Details
Main Authors: Carvalho, A.M (Author), Constantino, C.S (Author), Vinga, S. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Online Access:View Fulltext in Publisher