iGlioSub: an integrative transcriptomic and epigenomic classifier for glioblastoma molecular subtypes

iGlioSub: an integrative transcriptomic and epigenomic classifier for glioblastoma molecular subtypes

Background: Glioblastoma (GBM) is the most aggressive and prevalent primary brain tumor, with a median survival of 15 months. Advancements in multi-omics profiling combined with computational algorithms have unraveled the existence of three GBM molecular subtypes (Classical, Mesenchymal, and Proneur...

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Bibliographic Details
Main Authors: Ensenyat-Mendez, M. (Author), Íñiguez-Muñoz, S. (Author), Marzese, D.M (Author), Sesé, B. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
algorithm
area under the curve
Article
Cancer
controlled study
cost effectiveness analysis
cytokine release
diagnostic test accuracy study
differential gene expression
DNA methylation
DNA methylation age
epidermal growth factor receptor
epigenetics
Epigenetics
gene activation
gene control
gene expression
Gene expression
gene expression profiling
gene ontology
glioblastoma
Glioblastoma
hierarchical clustering
high throughput analysis
human
human tissue
iGlioSub
immune response
immunohistochemistry
Integrative classifier
integrative oncology
isocitrate dehydrogenase
Karnofsky Performance Status
machine learning
Machine learning
major clinical study
MAPK signaling
mitogen activated protein kinase 1
Molecular subtypes
multiomics
principal component analysis
random forest
receiver operating characteristic
single cell RNA seq
transcriptomics
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