Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma

Background: Hepatocellular carcinoma (HCC) is one of the most malignant tumors and the fourth leading cause of cancer-related death worldwide. Sorafenib is currently acknowledged as a standard therapy for advanced HCC. However, acquired resistance substantially limits the clinical efficacy of sorafe...

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Main Authors: Chen, Y. (Author), Hou, X. (Author), Huang, X. (Author), Li, D. (Author), Moorhead, J.F (Author), Rao, Y. (Author), Ruan, X.Z (Author), Su, Y. (Author), Varghese, Z. (Author), Wei, L. (Author), Yao, Y. (Author), You, Z. (Author), Zheng, G. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
adult
animal
animal cell
animal experiment
animal model
animal tissue
Animals
antineoplastic agent
apoptosis
Article
autophagy
Autophagy
autophagy (cellular)
cancer patient
cancer resistance
cancer surgery
cancer tissue
carbanilamide derivative
Carcinoma, Hepatocellular
cell assay
cell proliferation
chaperone
chemosensitivity
cholesterol
Cholesterol
coimmunoprecipitation
colony formation
controlled study
correlational study
disease association
drug resistance
Drug Resistance, Neoplasm
drug targeting
enzyme activity
female
genetics
Hepatocellular carcinoma (HCC)
hepatocellular carcinoma cell line
human
human cell
human tissue
Humans
hydroxymethylglutaryl coenzyme A reductase kinase
hypercholesterolemia
immunoblotting
immunofluorescence assay
immunohistochemistry
in vitro study
in vivo study
lipid storage
liver cell carcinoma
Liver Neoplasms
liver resection
liver tissue
liver tumor
lycorine
Lycorine
major clinical study
male
metabolism
Mice
Mice, Nude
middle aged
mouse
nonhuman
nude mouse
personalized medicine
Phenylurea Compounds
protein expression
protein function
protein inhibitor
protein lipid interaction
regulatory mechanism
SCAP
sorafenib
Sorafenib
Sorafenib resistant
sterol regulatory element binding protein cleavage activating protein
sterol regulatory element binding protein cleavage activating protein inhibitor
unclassified drug
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