Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma

Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma

Background: Osteosarcoma (OS) is a malignant bone tumor mostly occurring in children and adolescents, while chemotherapy resistance often develops and the mechanisms involved remain challenging to be fully investigated. Methods: Genome-wide CRISPR screening combined with transcriptomic sequencing we...

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Bibliographic Details
Main Authors: Cao, Z. (Author), Du, M. (Author), Gu, J. (Author), Heng, W. (Author), Liu, C. (Author), Liu, N. (Author), Qian, J. (Author), Wang, Y. (Author), Wei, F. (Author), Xue, X. (Author), Yu, Z. (Author), Zhang, W. (Author), Zhang, Y. (Author), Zhou, C. (Author), Zhu, K. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
adolescent
Adolescent
animal
Animals
Bone Neoplasms
bone tumor
clustered regularly interspaced short palindromic repeat
Clustered Regularly Interspaced Short Palindromic Repeats
DNA binding protein
DNA-Binding Proteins
doxorubicin
Doxorubicin
genetics
Genome-wide CRISPR screen
human
Humans
metabolism
Mice
mouse
osteosarcoma
Osteosarcoma
pathology
Rad18
RAD18 protein, human
RGD-exosome
ubiquitin protein ligase
Ubiquitin-Protein Ligases
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