Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology

Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology

Background: The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release of NETs in COVID-19 remain unclear. Objectives: We aim to investigate the role...

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Main Authors: Almeida, C.J.L.R (Author), Alves-Filho, J.C.F (Author), Amaral, N.B (Author), Arruda, E. (Author), Batah, S.S (Author), Benatti, M.N (Author), Bonjorno, L.P (Author), Caetité, D.B (Author), Castro, I.M.S (Author), Cebinelli, G.C.M (Author), Costa, V.F (Author), Cunha, F.Q (Author), Cunha, L.D (Author), Cunha, T.M (Author), da Fonseca, B.A.L (Author), Damasceno, L.E.A (Author), Espósito, D.L.A (Author), Fabro, A.T (Author), Giannini, M.C (Author), Gomes, G.F (Author), Gonçalves, A.V (Author), Gonçalves, T.T (Author), Leiria, L.O.S (Author), Lima, M.H.F (Author), Lopes, M.I.F (Author), Louzada-Junior, P. (Author), Martins, R.B (Author), Martins, T.V (Author), Monteiro, V.V.S (Author), Nakaia, H.I (Author), Nascimento, D.C (Author), Oliveira, R.D.R (Author), Paiva, I.M (Author), Pontelli, M.C (Author), Rodrigues, T.S (Author), Santana, R.C (Author), Schneider, A.H (Author), Silva, B.M.S (Author), Silva, C.M.S (Author), Silva, J.C (Author), Silva, J.C.S (Author), Toller-Kawahisa, J.E (Author), Vasconcelos, A.P (Author), Veras, F.P (Author), Wanderley, C.W.S (Author), Zamboni, D.S (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
COVID-19
Innate immunity
NETs
Neutrophil
Organ damage
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