4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation

Show other versions (1)

Background: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...

Full description

Bibliographic Details
Main Authors: Lim, S.M (Author), Mani, V. (Author), Narasimhan, B. (Author), Ramasamy, K. (Author), Shah, S.A.A (Author), Tahlan, S. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2019
Subjects:
2-Mercaptobenzimidazole derivatives
Antibacterial
Anticancer
Antifungal
p-Amino benzoic acid
Online Access:View Fulltext in Publisher
View in Scopus

Internet

View Fulltext in Publisher
View in Scopus

Similar Items