Blocking drug efflux mechanisms facilitate genome engineering process in hypercellulolytic fungus, Penicillium funiculosum NCIM1228

Blocking drug efflux mechanisms facilitate genome engineering process in hypercellulolytic fungus, Penicillium funiculosum NCIM1228

Background: Penicillium funiculosum NCIM1228 is a non-model filamentous fungus that produces high-quality secretome for lignocellulosic biomass saccharification. Despite having desirable traits to be an industrial workhorse, P. funiculosum has been underestimated due to a lack of reliable genetic en...

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Bibliographic Details
Main Authors: Gupta, M. (Author), Nair, A.M (Author), Ogunyewo, O.A (Author), Pasari, N. (Author), Randhawa, A. (Author), Sinha, T. (Author), Verma, P.K (Author), Verma, S. (Author), Yazdani, S.S (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Agrobacterium
Agrobacterium mediated transformations
Agrobacterium-mediated transformation
antibiotic resistance
Antibiotic selections
Antibiotics
Carbon
Cellobiohydrolase I
CRISPR/Cas9
DNA
Drug tolerance
Efficiency
Efflux pump inhibitors
enzyme
fungus
Gene-function analysis
Genes
genetic engineering
Genetic engineering
Genetic manipulations
genome
Genome modification
genomics
High level expression
Homologous recombination
Linear transformations
Mathematical transformations
Penicillium funiculosum
Plants (botany)
Saccharification
Transcriptome analysis
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