Overproduction of docosahexaenoic acid in Schizochytrium sp. through genetic engineering of oxidative stress defense pathways

Overproduction of docosahexaenoic acid in Schizochytrium sp. through genetic engineering of oxidative stress defense pathways

Background: Oxidation and peroxidation of lipids in microorganisms result in increased levels of intracellular reactive oxygen species (ROS) and reactive aldehydes, and consequent reduction of cell growth and lipid accumulation. Results: To reduce oxygen-mediated cell damage and increase lipid and d...

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Bibliographic Details
Main Authors: Chen, Z. (Author), Han, X. (Author), Li, Z. (Author), Wen, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
accumulation
Aldehyde dehydrogenase
Aldehydes
Batch cell culture
Cell engineering
Cell growth
Cell proliferation
Cells
cyanobacterium
defense behavior
Docosahexaenoic acid
fatty acid
Fed-batch cultures
gene expression
genetic engineering
Genetic engineering
Glucose-6-phosphate dehydrogenase
Glutathione peroxidase
Growth kinetics
growth rate
lipid
Lipid accumulations
Network security
oxidative stress
Oxidative stress
Oxidative stress defense pathway
Oxygen
reactive oxygen species
Scavenging ability
Schizochytrium
Schizochytrium sp
Thioredoxin reductase
Unsaturated fatty acids
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