Experimental and theoretical insights into the effects of pH on catalysis of bond-cleavage by the lignin peroxidase isozyme H8 from Phanerochaete chrysosporium

Experimental and theoretical insights into the effects of pH on catalysis of bond-cleavage by the lignin peroxidase isozyme H8 from Phanerochaete chrysosporium

Background: Lignin peroxidases catalyze a variety of reactions, resulting in cleavage of both β-O-4′ ether bonds and C–C bonds in lignin, both of which are essential for depolymerizing lignin into fragments amendable to biological or chemical upgrading to valuable products. Studies of the specificit...

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Bibliographic Details
Main Authors: Adams, P.D (Author), Deng, K. (Author), Northen, T.R (Author), Pham, L.T.M (Author), Sale, K.L (Author), Simmons, B.A (Author), Singer, S.W (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
Ab initio molecular dynamic simulations
Ab initio molecular dynamics
Aliphatic hydroxyl groups
catalysis
Catalysis
Catalysts
Chemical bonds
Chemical Bonds
degradation
Dimers
Energetic barriers
Ethers
experimental study
fungus
Isoenzymes
lignin
Lignin
Lignin degradation
Lignin depolymerization
Lignin peroxidase
Mass spectrometry
molecular analysis
Molecular dynamics
pH
pH effects
Phanerochaete chrysosporium
Phanerochaete Chrysosporium
Product distributions
Quantum calculation
Reaction conditions
theoretical study
Theoretical study
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