Identification and characterization of proteins of unknown function (PUFs) in Clostridium thermocellum DSM 1313 strains as potential genetic engineering targets

Identification and characterization of proteins of unknown function (PUFs) in Clostridium thermocellum DSM 1313 strains as potential genetic engineering targets

Background: Mass spectrometry-based proteomics can identify and quantify thousands of proteins from individual microbial species, but a significant percentage of these proteins are unannotated and hence classified as proteins of unknown function (PUFs). Due to the difficulty in extracting meaningful...

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Bibliographic Details
Main Authors: Cope, A.L (Author), Guss, A.M (Author), Hettich, R.L (Author), O’Dell, K.B (Author), Poudel, S. (Author), Seo, H. (Author), Trinh, C.T (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
bacterium
Clostridium
Clostridium thermocellum
Engineered strains
Functional activities
Functional information
genetic engineering
Genetic engineering
Guilt by associations
homology
identification method
mass spectrometry
Mass spectrometry
Metabolic engineering
Metabolic information
metabolism
Metabolism
Microbial species
protein
Proteins
proteomics
Proteomics
Putative functions
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