When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440

Background: Medium-chain-length α,ω-diols (mcl-diols) are important building blocks in polymer production. Recently, microbial mcl-diol production from alkanes was achieved in E. coli (albeit at low rates) using the alkane monooxygenase system AlkBGTL and esterification module Atf1. Owing to its rem...

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Bibliographic Details
Main Authors:	Akwafo, E.O (Author), Batianis, C. (Author), Lu, C. (Author), Martins dos Santos, V.A.P (Author), Weusthuis, R.A (Author), Wijffels, R.H (Author)
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2021
Subjects:	bacterium carbon Carbon Carbon catabolite repression Chain length Chains length Enzymes Escherichia coli ester Esterase Esters gene expression Genes growth Hexyl acetate Hydrolysis Medium-chain-length α,ω-diol Medium-chain-length α,ω-diols Metabolic versatility metabolism Metabolism Monooxygenase Monooxygenases Oxyfunctionalization Paraffins polymer Pseudomonas Pseudomonas putida Pseudomonas putida KT2440 substrate preference Substrate preference Substrates ω-Oxyfunctionalization Ω-oxyfunctionalization
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When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440

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