Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19

Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19

Background: Natural killer (NK) cells are innate lymphoid cells that mediate antitumour and antiviral responses. However, very little is known about how ageing influences human NK cells, especially at the single-cell level. Methods: We applied single-cell sequencing (scRNA-seq) to human lymphocytes...

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Bibliographic Details
Main Authors: Fang, J. (Author), Fu, B. (Author), Guo, C. (Author), Huang, B. (Author), Jin, L. (Author), Ni, F. (Author), Qu, K. (Author), Wang, D. (Author), Wang, P. (Author), Wei, H. (Author), Wu, M. (Author), Zhao, R. (Author), Zheng, M. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Ageing
COVID-19
NK cell
Single-cell RNA-seq
Type-I interferon
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