MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

Background: Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and a common cause of end-stage renal disease (ESRD). Mesenchymal stem cells (MSCs) possess potent anti-inflammatory and immunomodulatory properties, which render them an attractive therapeutic tool for tissue damage...

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Bibliographic Details
Main Authors: Du, H. (Author), He, J. (Author), Le, X. (Author), Li, C. (Author), Liu, M. (Author), Ouyang, Y. (Author), Rao, W. (Author), Tu, C. (Author), Wu, D. (Author), Zhang, K. (Author), Zhang, Y. (Author), Zheng, S. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Diabetic nephropathy
Macrophage polarization
Mesenchymal stem cells
MicroRNAs
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