Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway

Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway

Background: Bone marrow cells (BMCs), especially mesenchymal stem cells (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation in clinical translation. Based on the anti-inflammation and anti-apoptosis effect...

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Bibliographic Details
Main Authors: Chen, G. (Author), Gong, Z. (Author), Hu, M. (Author), Huang, P. (Author), Jiang, W. (Author), Jin, C. (Author), Li, X. (Author), Ning, Y. (Author), Qian, H. (Author), Tang, R. (Author), Wu, C. (Author), Xiong, Y. (Author), Xu, J. (Author), Yang, Y. (Author), Zhang, L. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Exosomes
Mesenchymal stem cells
Myocardial infarction
Pretreatment
Tongxinluo
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