Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation

Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation

The Shadoo and PrP prion protein family members are thought to be functionally related, but previous knockdown/knockout experiments in early mouse embryogenesis have provided seemingly contradictory results. In particular, Shadoo was found to be indispensable in the absence of PrP in knockdown analy...

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Bibliographic Details
Main Authors: Asset, A. (Author), Castille, J. (Author), Daniel-Carlier, N. (Author), Jaffrézic, F. (Author), Laloë, D. (Author), Lecardonnel, J. (Author), Moazami-Goudarzi, K. (Author), Moroldo, M. (Author), Passet, B. (Author), Rau, A. (Author), Vilotte, J.-L (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
lentivirus
Mouse
prion
robustness
Shadoo
ShRNA
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