KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma

KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma

Background: Kinase suppressor of Ras 2 (KSR2) is a regulator of MAPK signaling that is overactivated in most hepatocellular carcinoma (HCC). We sought to determine the role of KSR2 in HCC pathogenesis. Methods: We tested the level of KSR2 in HCC tissues and cell lines by tissue microarray, qPCR, and...

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Main Authors: Cai, J.-B (Author), Chai, X.-Q (Author), Fan, J. (Author), Gao, C. (Author), Guo, X.-J (Author), Huang, X.-Y (Author), Ke, A.-W (Author), Li, Y.-C (Author), Lu, J.-C (Author), Shi, G.-M (Author), Wang, S.-W (Author), Zhang, P.-F (Author), Zheng, Y.-M (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
14–3-3ζ
Hepatocellular carcinoma
KSR2
MAPK pathway
Sorafenib
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