Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia

Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices at an early age of onset. The disorder shows considerable clinical, pathological, and genetic heterogeneity. Here we investigated the proteomic signatures of frontal and temporal cortex from brains wi...

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Main Authors: de Veij Mestdagh, C.F (Author), Ganz, A.B (Author), Heutink, P. (Author), Holstege, H. (Author), Hondius, D.C (Author), Koopmans, F.T.W (Author), Li, K.W (Author), Melhem, S. (Author), Menden, K. (Author), Miedema, S.S.M (Author), Mol, M.O (Author), Paliukhovich, I. (Author), Rizzu, P. (Author), Smit, A.B (Author), van Kesteren, R.E (Author), van Nierop, P. (Author), van Rooij, J. (Author), van Swieten, J.C (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Cell type enrichment
Frontotemporal dementia
GRN
Human brain proteomics
MAPT
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