Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, AppNL-F/NL-F and AppNL-G-F/NL-G-F, exhibiting AD-like Aβ pathology to analyze how the brain pathologie...

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Bibliographic Details
Main Authors: Abelein, A. (Author), Bergquist, J. (Author), Chen, G. (Author), Frykman, S. (Author), Fujioka, R. (Author), Gobom, J. (Author), Hammarström, P. (Author), Haret, R.M (Author), Haytural, H. (Author), Jelic, V. (Author), Jiang, R. (Author), Li, H. (Author), Nilsson, P. (Author), Nyström, S. (Author), Saido, T.C (Author), Sasaguri, H. (Author), Sekiguchi, M. (Author), Shevchenko, G. (Author), Smailovic, U. (Author), Syvänen, S. (Author), Tijms, B.M (Author), Visser, P.J (Author), Watamura, N. (Author), Winblad, B. (Author), Zetterberg, H. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Alzheimer’s disease
Amyloid-β (Aβ)
App knock-in mice
Autophagy
Cerebrospinal fluid
Choroid plexus
Decorin
Extracellular matrix
Mass spectrometry
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