Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation of alpha-synuclein (aSyn) within neurons in the brain. Predominately pre-synaptic, aSyn has been reported in various subcellular compartments in experimental models. Indeed, nuclear alpha-synuclein (aSynNuc) is...

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Bibliographic Details
Main Authors: Attems, J. (Author), Erskine, D. (Author), Koss, D.J (Author), Leite, M. (Author), Menon, H. (Author), Outeiro, T.F (Author), Palmoski, P. (Author), Porter, A. (Author), Todd, O.G.J (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Alpha-synuclein
Dementia with Lewy bodies
Lewy body disease
Nuclear pathology
Synucleinopathies
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