Structure-guided protein engineering of ammonia lyase for efficient synthesis of sterically bulky unnatural amino acids
Enzymatic asymmetric amination addition is seen as a promising approach for synthesizing amine derivatives, especially unnatural amino acids, which are valuable precursors to fine chemicals and drugs. Despite the broad substrate spectrum of methylaspartate lyase (MAL), some bulky substrates, such as...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media Deutschland GmbH
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |