Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice

Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice

Background: Acrylamide (AA) is a rodent carcinogen and classified by the IARC into Group 2A (probable human carcinogen). AA has been reported to induce mutations in transgenic rodent gene mutation assays (TGR assays), the extent of which is presumed to depend on exposure length and the duration of e...

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Bibliographic Details
Main Authors: Furukawa, S. (Author), Hagio, S. (Author), Hayashi, S. (Author), Honma, M. (Author), Kuroda, Y. (Author), Masumura, K. (Author), Takeuchi, K. (Author), Tsuji, N. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
acrylamide
Acrylamide
animal cell
animal experiment
animal model
animal tissue
Article
blood analysis
blood sampling
comparative study
controlled study
DNA fragment
DNA isolation
DNA sequencing
erythrocyte
ethylnitrosourea
gene mutation
genomic DNA
germ cell
Germ cell
gpt delta mouse
gpt delta transgenic mouse
lung parenchyma
male
micronucleus test
mouse
mutagenicity
Mutagenicity
mutation rate
mutational analysis
nonhuman
somatic cell
somatic mutation
sperm
spermatogenesis
spermatogonium
testis tissue
transgenic rodent gene mutation assay
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