In vivo comet assay in rabbit corneal epithelial cells following ocular instillation with genotoxic compounds

In vivo comet assay in rabbit corneal epithelial cells following ocular instillation with genotoxic compounds

Background: The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, the levels of systemic drug exposure following systemic administration are of...

Full description

Bibliographic Details
Main Authors: Haranosono, Y. (Author), Kurata, M. (Author), Tahara, H. (Author), Yamagiwa, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
4 nitroquinoline 1 oxide
acrylamide
animal cell
animal experiment
animal model
animal tissue
antioxidant
Article
comet assay
Comet assay
comparative study
controlled study
cornea epithelium
cornea tissue
Corneal epithelial cells
cytochrome P450
dimethyl sulfoxide
DNA damage
DNA strand breakage
Drug development
drug exposure
epithelium cell
ethidium bromide
eye toxicity
genotoxicity
Genotoxicity test
in vivo study
Japanese White (rabbit)
Leporidae
liver cell
male
mesylic acid methyl ester
nonhuman
Ophthalmic drug
paraquat
Rabbit
sodium chloride
toxic substance
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items