PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40

PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40

Background: Peroxiredoxin 1 (PRDX1) is a member of a ubiquitous family of thiol peroxidases that catalyze the reduction of peroxides, including hydrogen peroxide. It functions as an antioxidant enzyme, similar to catalase and glutathione peroxidase. PRDX1 was recently shown act as a sensor of reacti...

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Bibliographic Details
Main Authors: Moriwaki, T. (Author), Sasanuma, H. (Author), Seki, M. (Author), Takeda, S. (Author), Tamari, Y. (Author), Tano, K. (Author), Yoshimura, A. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
animal cell
Article
cell death
cell growth
cell viability
chromosome aberration
chromosome breakage
chromosome damage
controlled study
DNA damage
DT40 cell line
fluorescent dye
genomic instability
human
mercaptoethanol
messenger RNA
nonhuman
oxidative stress
peroxiredoxin 1
reactive oxygen metabolite
sister chromatid exchange
Western blotting
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