multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination

multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination

Background: Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABAARs). Positron Emission Tomography (PET) imaging of the GABAARs with [11C]FMZ has been used to evidence al...

Full description

Bibliographic Details
Main Authors: Atack, J.R (Author), Caygill, C. (Author), Destro, G. (Author), Gendron, T. (Author), Gouverneur, V. (Author), Guibbal, F. (Author), Hueting, R. (Author), Marshall, C. (Author), Sap, J.B.I (Author), Straathof, N.J.W (Author), Tredwell, M. (Author), Vriamont, C. (Author), Warnier, C. (Author), Watkins, A.J (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
[18F]Flumazenil
18F Flumazenil
anion exchange
aqueous solution
Article
Automation
drug dose
drug synthesis
flame ionization detection
flumazenil
fluorination
Fluorine-18
gas chromatography
good manufacturing practice
Good manufacturing practice
high performance liquid chromatography
in vitro study
inductively coupled plasma mass spectrometry
multi patient dose synthesis
nonhuman
Positron emission tomography
practice guideline
quality control
radiochemistry
solid phase extraction
tetrabutylammonium
unclassified drug
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items