TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic C. elegans

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic C. elegans

While amyloid (A) β and tau aggregates define the neuropathology of Alzheimer's disease (AD), TDP-43 has recently emerged as a co-morbid pathology in over half of patients with AD. Individuals with concomitant Aβ, tau, and TDP-43 pathology experience accelerated cognitive decline and worsened b...

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Bibliographic Details
Main Authors: Bird, T.D (Author), Currey, H.N (Author), Dirk Keene, C. (Author), Hincks, J.C (Author), Kraemer, B.C (Author), Latimer, C.S (Author), Liachko, N.F (Author), Stair, J.G (Author)
Format: Article
Language:English
Published: Company of Biologists Ltd 2022
Subjects:
Alzheimer's disease
amyloid β (Aβ)
C. elegans
proteotoxicity
tau
TDP-43
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