Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation

Quantitative traits are measurable phenotypes that show continuous variation over a wide phenotypic range. Enormous effort has recently been put into determining the genetic influences on a variety of quantitative traits with mixed success. We identified a quantitative trait in a tractable model sys...

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Bibliographic Details
Main Authors:	Hong, J. (Author), Hua, B. (Author), Palme, J. (Author), Springer, M. (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2021
Subjects:	Article biological model biology carbohydrate metabolism Computational Biology computer model computer simulation Computer Simulation concentration (parameter) fungal strain fungus isolation Gal3 protein, S cerevisiae GAL80 protein, S cerevisiae galactose Galactose gene expression regulation Gene Expression Regulation, Fungal genetic variation Genetic Variation genetics glucose transporter mathematical model Metabolic Networks and Pathways metabolism Models, Biological Monosaccharide Transport Proteins mutation Mutation negative feedback nonhuman nutrimetabolomics phenotype Phenotype phenotypic variation quantitative trait Quantitative Trait, Heritable repressor protein Repressor Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae protein Saccharomyces cerevisiae Proteins transcription factor Transcription Factors yeast
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Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation

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