Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in down syndrome

Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in down syndrome

Trisomy of human chromosome 21 (HSA21) causes Down syndrome (DS). The trisomy does not simply result in the upregulation of HSA21-encoded genes but also leads to a genome-wide transcriptomic deregulation, which affect differently each tissue and cell type as a result of epigenetic mechanisms and pro...

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Bibliographic Details
Main Authors: de Toma, I. (Author), Dierssen, M. (Author), Sierra, C. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
Animals
Article
biology
cell activation
chromosome 21
Chromosomes, Human, Pair 21
Computational Biology
Databases, Genetic
disease model
Disease Models, Animal
Down syndrome
Down Syndrome
gene expression profiling
Gene Expression Profiling
gene expression regulation
Gene Expression Regulation
gene interaction
gene ontology
Gene Ontology
gene regulatory network
Gene Regulatory Networks
genetic database
genetics
human
Humans
inflammatory disease
interferon
Interferons
leukocyte activation
meta analysis
Mice
mouse
neutrophil
Neutrophil Activation
nonhuman
protein interaction
software
Software
transcriptomics
trisomy
trisomy 21
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