FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution

FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution

Secondary metabolites (SMs) are a vast group of compounds with different structures and properties that have been utilized as drugs, food additives, dyes, and as monomers for novel plastics. In many cases, the biosynthesis of SMs is catalysed by enzymes whose corresponding genes are co-localized in...

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Bibliographic Details
Main Authors: Derntl, C. (Author), Mach, R.L (Author), Mach-Aigner, A.R (Author), Schaffer, D. (Author), Vignolle, G.A (Author), Zehetner, L. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
algorithm
amino acid sequence
Article
Aspergillus
automation
biology
biosynthesis
biosynthetic gene cluster
Biosynthetic Pathways
coevolution
Computational Biology
data mining
database management system
Databases, Protein
essential gene
Evolution, Molecular
fungal examination
fungal genome
fungal protein
Fungal Proteins
Fungi
fungus
gene cluster
gene identification
gene location
Genes, Essential
Genes, Synthetic
genetic database
genetic transcription
genetics
Genome, Fungal
genomics
Genomics
heterologous expression
Lovastatin
metabolism
metabolite
mevinolin
molecular evolution
multigene family
Multigene Family
nonhuman
phylogenetic tree
phylogeny
Phylogeny
protein database
proteome
Proteome
secondary metabolite
sequence alignment
software
Software
synthetic DNA
transcriptome
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