The impact of whole genome duplications on the human gene regulatory networks

The impact of whole genome duplications on the human gene regulatory networks

This work studies the effects of the two rounds of Whole Genome Duplication (WGD) at the origin of the vertebrate lineage on the architecture of the human gene regulatory networks. We integrate information on transcriptional regulation, miRNA regulation, and protein-protein interactions to comparati...

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Bibliographic Details
Main Authors: Caselle, M. (Author), Mottes, F. (Author), Osella, M. (Author), Villa, C. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
Animals
Article
biological model
Evolution, Molecular
feed forward neural network
gene duplication
Gene Duplication
gene regulatory network
Gene Regulatory Networks
genetics
Genome, Human
genomics
Genomics
human
human genetics
human genome
Humans
microRNA
Models, Genetic
molecular evolution
noise reduction
protein protein interaction
retinoic acid receptor
retinoid X receptor
signal processing
small scale duplication
transcription factor
transcription regulation
vertebrate
Vertebrates
whole genome duplication
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