Numerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemes

Numerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemes

Pre-exposure prophylaxis (PrEP) is an important pillar to prevent HIV transmission. Because of experimental and clinical shortcomings, mathematical models that integrate pharmacological, viral- and host factors are frequently used to quantify clinical efficacy of PrEP. Stochastic simulations of thes...

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Bibliographic Details
Main Authors: von Kleist, M. (Author), Wang, J. (Author), Zhang, L. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
anti human immunodeficiency virus agent
Anti-HIV Agents
Article
biology
Computational Biology
computer model
computer simulation
Computer Simulation
controlled study
disease duration
dolutegravir
drug dose regimen
drug efficacy
drug monitoring
Drug Monitoring
feasibility study
HIV Infections
HIV-1
human
Human immunodeficiency virus 1
Human immunodeficiency virus infection
Humans
major clinical study
Markov chain
molecular dynamics
pharmacodynamic parameters
pharmacokinetic parameters
post exposure prophylaxis
prediction
pre-exposure prophylaxis
Pre-Exposure Prophylaxis
procedures
quantitative study
stochastic model
Stochastic Processes
treatment outcome
Treatment Outcome
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