Crowdsourced identification of multi-target kinase inhibitors for RET- And TAU- based disease- And Multi-Targeting Drug DREAM Challenge

Crowdsourced identification of multi-target kinase inhibitors for RET- And TAU- based disease- And Multi-Targeting Drug DREAM Challenge

A continuing challenge in modern medicine is the identification of safer and more efficacious drugs. Precision therapeutics, which have one molecular target, have been long promised to be safer and more effective than traditional therapies. This approach has proven to be challenging for multiple rea...

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Bibliographic Details
Main Authors: Abagyan, R. (Author), Allaway, R.J (Author), Cagan, R. (Author), Carlson, H.A (Author), Dang, K.K (Author), Das, T.K (Author), Guinney, J. (Author), Guo, X. (Author), Hecht, C. (Author), Jeon, H. (Author), Jeon, M. (Author), Jiang, H. (Author), Kang, J. (Author), Ko, M. (Author), Lee, J. (Author), Park, D. (Author), Schlessinger, A. (Author), Tan, A.C (Author), Tropsha, A. (Author), Xiong, Z. (Author), Zheng, M. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal experiment
Article
artificial neural network
chemical analysis
chemistry
computer model
crowdsourcing
drug development
Drug Development
female
genetics
human
Humans
machine learning
male
MAPT protein, human
mathematical computing
metabolism
neoplasm
Neoplasms
Neural Networks, Computer
nonhuman
phosphotransferase inhibitor
polypharmacology
Polypharmacology
prediction
process design
protein kinase inhibitor
Protein Kinase Inhibitors
protein Ret
Proto-Oncogene Proteins c-ret
RET protein, human
tau protein
tau Proteins
Tauopathies
tauopathy
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