Mathematical model of a personalized neoantigen cancer vaccine and the human immune system

Mathematical model of a personalized neoantigen cancer vaccine and the human immune system

Cancer vaccines are an important component of the cancer immunotherapy toolkit enhancing immune response to malignant cells by activating CD4+ and CD8+ T cells. Multiple successful clinical applications of cancer vaccines have shown good safety and efficacy. Despite the notable progress, significant...

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Bibliographic Details
Main Authors: McGill, J.R (Author), Messan, M.R (Author), Nukala, U. (Author), Sauna, Z.E (Author), Yang, H. (Author), Yogurtcu, O.N (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
antigen presenting cell
Antigens, Neoplasm
Article
cancer immunization
cancer vaccine
Cancer Vaccines
gene dosage
human
Humans
immune system
immunology
immunotherapy
Immunotherapy
lymphocyte count
major histocompatibility antigen class 1
major histocompatibility antigen class 2
mathematical model
melanoma
Melanoma
Models, Theoretical
neoantigen cancer vaccine
personalized medicine
Precision Medicine
procedures
T lymphocyte
theoretical model
T-Lymphocytes
treatment outcome
Treatment Outcome
tumor antigen
tumor volume
unclassified drug
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