Differential contribution to gene expression prediction of histone modifications at enhancers or promoters

Differential contribution to gene expression prediction of histone modifications at enhancers or promoters

The ChIP-seq signal of histone modifications at promoters is a good predictor of gene expression in different cellular contexts, but whether this is also true at enhancers is not clear. To address this issue, we develop quantitative models to characterize the relationship of gene expression with his...

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Bibliographic Details
Main Authors: Ballaré, C. (Author), Beringer, M. (Author), Blanco, E. (Author), Di Croce, L. (Author), González-Ramírez, M. (Author), Mugianesi, F. (Author), Santanach, A. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
Animals
article
biological model
biology
cell culture
cell differentiation
Cell Differentiation
Cells, Cultured
Chromatin Immunoprecipitation Sequencing
Computational Biology
embryonic stem cell
Enhancer Elements, Genetic
enhancer region
gene expression
Gene Expression
genetics
histone code
Histone Code
histone modification
human
human cell
Humans
metabolism
Mice
Models, Genetic
mouse
mouse embryonic stem cell
Mouse Embryonic Stem Cells
prediction
promoter region
Promoter Regions, Genetic
regression analysis
Regression Analysis
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