Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons

Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons

Two subpopulations of midbrain dopamine (DA) neurons are known to have different dynamic firing ranges in vitro that correspond to distinct projection targets: the originally identified conventional DA neurons project to the dorsal striatum and the lateral shell of the nucleus accumbens, whereas an...

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Bibliographic Details
Main Authors: Canavier, C.C (Author), Hammer, N. (Author), Knowlton, C.J (Author), Roeper, J. (Author), Ziouziou, T.I (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
action potential
Action Potentials
animal
animal cell
Animals
Article
biological model
biology
biophysics
C57BL mouse
channel gating
Computational Biology
computer model
controlled study
cytology
depolarization
dopaminergic nerve cell
Dopaminergic Neurons
dorsal striatum
Electrophysiological Phenomena
electrophysiology
in vitro study
In Vitro Techniques
Ion Channel Gating
limbic cortex
long term depression
Long-Term Synaptic Depression
male
Male
Markov chain
Markov Chains
mesencephalon
Mesencephalon
Mice
Mice, Inbred C57BL
Models, Neurological
mouse
nerve potential
nerve projection
neurotransmission
nonhuman
nucleus accumbens
patch clamp technique
Patch-Clamp Techniques
physiology
potassium
potassium conductance
prefrontal cortex
sodium channel
sodium conductance
sodium ion
voltage gated sodium channel
Voltage-Gated Sodium Channels
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