Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2

Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2

Apart from the canonical fingers, palm and thumb domains, the RNA dependent RNA polymerases (RdRp) from the viral order Nidovirales possess two additional domains. Of these, the function of the Nidovirus RdRp associated nucleotidyl transferase domain (NiRAN) remains unanswered. The elucidation of th...

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Bibliographic Details
Main Authors: Ahmad, M. (Author), Bhattacharyya, S. (Author), Biswal, B.K (Author), Chakraborty, S. (Author), Dwivedy, A. (Author), Jeyakanthan, J. (Author), Kar, D. (Author), Majumdar, T. (Author), Mani, S. (Author), Mariadasse, R. (Author), Sonar, S. (Author), Tailor, P. (Author), Tiwari, S. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
2,3 dihydro 2 oxo 3 (4,5,6,7 tetrahydro 1h indol 2 ylmethylene) 1h indole 5 sulfonic acid dimethylamide
angiotensin converting enzyme 2
Antiviral Agents
antivirus agent
Article
Catalytic Domain
chemistry
combination chemotherapy
computer model
computer simulation
Computer Simulation
coronavirus disease 2019
Coronavirus RNA-Dependent RNA Polymerase
drug determination
drug effect
drug potentiation
drug targeting
enzyme active site
enzyme activity
enzyme binding
ex vivo study
human
Humans
infected cell
infection
mass spectrometry
mathematical model
metabolism
molecular docking
monotherapy
mutant protein
Nidovirus RNA dependent RNA polymerase associated nucleotidyl transferase domain protein
nonhuman
nucleoside triphosphate
pandemic
phosphotransferase
prediction
protein binding
protein domain
Protein Domains
protein folding
remdesivir
RNA polymerase
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
sorafenib
unclassified drug
viral protein
virus inhibition
virus load
virus strain
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