Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV

The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of B cell receptor (BCR) affinity maturation that emp...

Full description

Bibliographic Details
Main Authors: Chakraborty, A.K (Author), Conti, S. (Author), Faris, J.G (Author), Karplus, M. (Author), Ovchinnikov, V. (Author), Sprenger, K.G (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
AIDS Vaccines
Antibodies, Neutralizing
Broadly Neutralizing Antibodies
HIV Antibodies
HIV Infections
HIV-1
human
Human immunodeficiency virus 1
Human immunodeficiency virus antibody
Human immunodeficiency virus infection
Human immunodeficiency virus vaccine
Humans
neutralizing antibody
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items