Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling

Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling

Numerous stages of organismal development rely on the cellular interpretation of gradients of secreted morphogens including members of the Bone Morphogenetic Protein (BMP) family through transmembrane receptors. Early gradients of BMPs drive dorsal/ventral patterning throughout the animal kingdom in...

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Bibliographic Details
Main Authors: Dutko, J.A (Author), Madamanchi, A. (Author), Mullins, M.C (Author), Shahriar Karim, M. (Author), Umulis, D.M (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
Animals
Article
binding affinity
biological model
biology
Biophysical Phenomena
biophysics
bone morphogenetic protein
bone morphogenetic protein receptor
Bone Morphogenetic Protein Receptors
Bone Morphogenetic Proteins
cells by body anatomy
chemistry
Computational Biology
computer simulation
Computer Simulation
concentration (parameter)
dynamics
enzyme activity
heterodimer
heterodimerization
homooligomerization
kinetics
ligand
Ligands
metabolism
Models, Biological
Models, Molecular
molecular model
morphogen
morphogenesis
Morphogenesis
nonhuman
phosphotransferase
protein multimerization
Protein Multimerization
protein quaternary structure
Protein Structure, Quaternary
signal transduction
Signal Transduction
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