Acetylcholine-gated current translates wake neuronal firing rate information into a spike timing-based code in Non-REM sleep, stabilizing neural network dynamics during memory consolidation

Sleep is critical for memory consolidation, although the exact mechanisms mediating this process are unknown. Combining reduced network models and analysis of in vivo recordings, we tested the hypothesis that neuromodulatory changes in acetylcholine (ACh) levels during non-rapid eye movement (NREM)...

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Bibliographic Details
Main Authors:	Aton, S.J (Author), Clawson, B.C (Author), Eniwaye, B. (Author), Ognjanovski, N. (Author), Shaver, J. (Author), Skilling, Q.M (Author), Zochowski, M. (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2021
Subjects:	acetylcholine Acetylcholine action potential Action Potentials animal animal experiment animal tissue Animals Article biological model biology C57BL mouse Computational Biology computer simulation Computer Simulation controlled study firing rate functional connectivity hippocampal CA1 region hippocampus Hippocampus in vivo study interneuron learning Learning male Male memory consolidation Memory Consolidation Mice Mice, Inbred C57BL Models, Neurological mouse nerve cell nerve cell network nerve cell plasticity Nerve Net Neural Networks, Computer Neuronal Plasticity Neurons nonhuman nonREM sleep physiology prediction sleep deprivation sleep stage Sleep Stages spike timing dependent plasticity wakefulness
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Acetylcholine-gated current translates wake neuronal firing rate information into a spike timing-based code in Non-REM sleep, stabilizing neural network dynamics during memory consolidation

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