Atorvastatin-mediated rescue of cancer-related cognitive changes in combined anticancer therapies

Atorvastatin-mediated rescue of cancer-related cognitive changes in combined anticancer therapies

Acute administration of trastuzumab (TZB) may induce various forms of cognitive impairment. These cancer-related cognitive changes (CRCC) are regulated by an adverse biological process involving cancer stem cells (CSCs) and IL-6. Recent studies have reported that atorvastatin (ATV) may change the dy...

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Bibliographic Details
Main Authors: Kim, J.S (Author), Kim, Y. (Author), Lee, J. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
antineoplastic agent
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
apoptosis
Article
atorvastatin
Atorvastatin
biological model
biology
cancer related cognitive change
cancer stem cell
cell density
cell interaction
cell proliferation
Cell Proliferation
cognitive defect
Cognitive Dysfunction
Computational Biology
controlled study
cytokine
cytokine release
Cytokines
drug effect
human
Humans
immunoglobulin enhancer binding protein
interleukin 6
intracellular signaling
long term care
mathematical model
metabolism
Models, Biological
neoplasm
Neoplasms
Neoplastic Stem Cells
pathophysiology
protein Bax
protein bcl 2
signal transduction
Signal Transduction
trastuzumab
Trastuzumab
tumor cell
tumor cell culture
Tumor Cells, Cultured
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