Experiment level curation of transcriptional regulatory interactions in neurodevelopment

Experiment level curation of transcriptional regulatory interactions in neurodevelopment

To facilitate the development of large-scale transcriptional regulatory networks (TRNs) that may enable in-silico analyses of disease mechanisms, a reliable catalogue of experimentally verified direct transcriptional regulatory interactions (DTRIs) is needed for training and validation. There has be...

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Bibliographic Details
Main Authors: Chang, T.H.C (Author), Chu, E.C.-P (Author), Liu, C.C (Author), Morin, A. (Author), Nguyen, T. (Author), Pavlidis, P. (Author), Sharma, A. (Author), Tsai, Y.-C (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
animal
Animals
Article
assay
biology
brain
Brain
brain development
central nervous system
chemistry
clinical protocol
Computational Biology
conceptual framework
differential gene expression
DNA
experimental study
gene expression regulation
Gene Expression Regulation
gene regulatory network
Gene Regulatory Networks
gene targeting
genetics
growth, development and aging
high throughput analysis
human
Humans
mammal
metabolism
Mice
molecular interaction
mouse
nervous system development
protein binding
Protein Binding
protein depletion
protein DNA binding
transcription factor
transcription factor PAX6
transcription factor reporter assay
Transcription Factors
transcription regulation
transcriptional regulatory interaction
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