All2: A tool for selecting mosaic mutations from comprehensive multi-cell comparisons

All2: A tool for selecting mosaic mutations from comprehensive multi-cell comparisons

Accurate discovery of somatic mutations in a cell is a challenge that partially lays in immaturity of dedicated analytical approaches. Approaches comparing a cell’s genome to a control bulk sample miss common mutations, while approaches to find such mutations from bulk suffer from low sensitivity. W...

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Bibliographic Details
Main Authors: Abyzov, A. (Author), Bae, T. (Author), Fasching, L. (Author), Jang, Y. (Author), Mariani, J. (Author), Sarangi, V. (Author), Sekar, S. (Author), Suvakov, M. (Author), Tomasini, L. (Author), Vaccarino, F.M (Author)
Format: Article
Language:English
Published: Public Library of Science 2022
Subjects:
article
cell lineage
controlled study
exome
false positive result
filtration
gene amplification
gene frequency
germ line
human cell
indel mutation
nucleic acid base substitution
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