Slipknotted and unknotted monovalent cation-proton antiporters evolved from a common ancestor

Slipknotted and unknotted monovalent cation-proton antiporters evolved from a common ancestor

While the slipknot topology in proteins has been known for over a decade, its evolutionary origin is still a mystery. We have identified a previously overlooked slipknot motif in a family of two-domain membrane transporters. Moreover, we found that these proteins are homologous to several families o...

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Bibliographic Details
Main Authors: Dunin-Horkawicz, S. (Author), Jarmolinska, A.I (Author), Jastrzebski, B. (Author), Perlinska, A.P (Author), Sulkowska, J.I (Author), Zayats, V. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
Amino Acid Motifs
antiporter
Antiporters
Article
biology
chemistry
Computational Biology
Databases, Protein
Evolution, Molecular
genetics
membrane protein
metabolism
molecular evolution
monovalent cation
monovalent cation proton antiporter
phylogeny
Phylogeny
protein conformation
Protein Conformation
protein database
protein domain
protein family
protein folding
protein localization
protein motif
protein structure
proton
slipknot motif
unclassified drug
unknotted motif
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