Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance

Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and found that the sensitivity to MEK inhibitors varied drastically between these cell lines...

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Bibliographic Details
Main Authors: Beule, D. (Author), Blanc, E. (Author), Blüthgen, N. (Author), Dorel, M. (Author), Eggert, A. (Author), Hertwig, F. (Author), Klinger, B. (Author), Mari, T. (Author), Messerschmidt, C. (Author), Nadler-Holly, M. (Author), Schulte, J.H (Author), Selbach, M. (Author), Sieber, A. (Author), Toedling, J. (Author), Ziehm, M. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
5 chloro 4 [[2 (isopropylsulfonyl)phenyl]amino] 2 [[2 methoxy 4 [4 (4 methyl 1 piperazinyl) 1 piperidinyl]phenyl]amino]pyrimidine
8 [4 (1 aminocyclobutyl)phenyl] 9 phenyl 1,2,4 triazolo[3,4 f][1,6]naphthyridin 3(2h) one
Article
biological model
cancer combination chemotherapy
cancer resistance
Cell Line, Tumor
CHP212 cell line
drug effect
drug resistance
Drug Resistance, Neoplasm
drug screening
Drug Screening Assays, Antitumor
drug sensitivity
Feedback
feedback system
human
human cell
Humans
IMR-32 cell line
Kelly cell line
LAN6 cell line
MAP Kinase Signaling System
MAPK signaling
mathematical model
metabolism
mitogen activated protein kinase kinase inhibitor
Models, Biological
molecularly targeted therapy
N206 cell line
NBEBC1 cell line
negative feedback
neuroblastoma
Neuroblastoma
neuroblastoma cell line
NGP cell line
phosphoproteomics
pictilisib
protein kinase inhibitor
Protein Kinase Inhibitors
quantitative analysis
Receptor, IGF Type 1
Receptor, IGF Type 2
selonsertib
selumetinib
signal transduction
Signal Transduction
sirolimus
SK-N-AS cell line
SK-N-SH cell line
somatomedin B receptor
somatomedin C receptor
sorafenib
tumor cell line
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