Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia

Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia

Regulation of cytosolic calcium (Ca2+) dynamics is fundamental to microglial function. Temporal and spatial Ca2+ fluxes are induced from a complicated signal transduction pathway linked to brain ionic homeostasis. In this paper, we develop a novel biophysical model of Ca2+ and sodium (Na+) dynamics...

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Bibliographic Details
Main Authors: Bithell, A. (Author), Dallas, M. (Author), Liu, J. (Author), McDaid, L. (Author), Poshtkohi, A. (Author), Wade, J. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
adenosine triphosphatase
adenosine triphosphate
Adenosine Triphosphate
algorithm
Algorithms
Article
biological model
calcium
Calcium
calcium cell level
calcium channel
cell membrane
Cell Membrane
cell membrane potential
complex formation
electrophysiology
human
human cell
Humans
hydrolysis
Hydrolysis
ion conductance
mathematical model
membrane potential
Membrane Potentials
metabolism
microglia
Microglia
Models, Biological
physiology
protein expression
protein hydrolysis
purinergic P2X receptor
purinergic P2X4 receptor
purinergic P2X7 receptor
Receptors, Purinergic P2X
signal transduction
sodium
Sodium
sodium calcium exchange protein
sodium cell level
sodium channel
Sodium-Calcium Exchanger
sodium-calcium exchanger 1
stoichiometry
whole cell patch clamp
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