Perspectives for the reconstruction of 3D chromatin conformation using single cell Hi-C data

Perspectives for the reconstruction of 3D chromatin conformation using single cell Hi-C data

Construction of chromosomes 3D models based on single cell Hi-C data constitute an important challenge. We present a reconstruction approach, DPDchrom, that incorporates basic knowledge whether the reconstructed conformation should be coil-like or globular and spring relaxation at contact sites. In...

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Bibliographic Details
Main Authors: Chertovich, A.V (Author), Galitsyna, A.A (Author), Gelfand, M.S (Author), Kos, P.I (Author), Razin, S.V (Author), Ulianov, S.V (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
algorithm
Algorithms
animal
animal cell
Animals
Article
benchmarking
chemistry
chromatin
Chromatin
chromatin conformation
conformation
contact density
contact radius change
controlled study
density
embryo
female
intermethod comparison
measurement accuracy
methodology
Mice
Modified Jaccard Index
mouse
nonhuman
parameters
procedures
protein conformation
Protein Conformation
random contact sampling
single cell analysis
Single-Cell Analysis
spatial orientation
three dimensional chromatin conformation reconstruction
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