The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function

The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function

We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical experiments and NMR spectroscopy, we found that Ten-Eleven translocation (TET) dioxygenases generate an epigenetic variant with structural and p...

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Bibliographic Details
Main Authors: Battistini, F. (Author), Brun-Heath, I. (Author), Castellazzi, C.L (Author), Dans, P.D (Author), González, C. (Author), Labrador, M. (Author), Orozco, M. (Author), Portella, G. (Author), Terrazas, M. (Author), Villegas, N. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
5 hydroxymethylcytosine
5 methylcytosine
5-hydroxymethylcytosine
5-Methylcytosine
Article
binding site
Binding Sites
biological model
biology
Biophysical Phenomena
biophysics
chemistry
chromatin assembly and disassembly
chromatin structure
Computational Biology
conformation
controlled study
cytosine
DNA
DNA methylation
DNA Methylation
DNA modification
DNA structure
double stranded DNA
Epigenesis, Genetic
epigenetics
experimental study
gene activity
genetic epigenesis
genetics
human
Humans
hydroxylation
in vitro study
Magnetic Resonance Spectroscopy
metabolism
Models, Biological
molecular dynamics
Molecular Dynamics Simulation
nuclear magnetic resonance spectroscopy
Nucleic Acid Conformation
nucleosome
theoretical study
thermodynamics
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